Label-Free LFC™ Analysis

The biopharmaceutical world is evolving rapidly, bringing with it the need for innovative technologies to support this fast-paced and changing environment. LumaCyte’s advanced bioanalytics platform, Radiance®, is a label-free, single cell approach for quantitative characterization of innate cellular responses without the need for antibody or genetic labeling. This revolutionary technology utilizes Laser Force Cytology™ (LFC™) to measure cellular response and changes to their intrinsic biochemical and biophyscial properties by measuring optical and fluidic forces on cells in a microfluidic device. Subtle cellular changes can be precisely captured with Radiance’s automated workflow, allowing developers to measure real-time product quality attributes and immediately optimize processes, significantly improving both production quality and product yields. This includes both in-process analytics to inform and optimize the production process as well as offline release and potency assays used to ensure product quality and consistency.

LFC detects subtle phenotypic changes in cells, rapidly measuring quantitative early indicators of cellular response including viral infection, transfection and differentiation.

Advanced bioanalytics are becoming a vital component of a successful Quality by Design (QbD) biomanufacturing program, where accurate and precise real-time data hold the keys to improved production consistency and product quality. LumaCyte’s label-free single-cell analysis platform, Radiance®, using Laser Force Cytology™ (LFC™), delivers advanced analytics for real-time bioprocess monitoring and quality control strategies.