LumaCyte’s transformative microfluidic cell analysis technology, Laser Force Cytology™ (LFC), offers researchers and biomanufacturers a label-free single cell analysis capability where the use of antibodies or genetic labeling is not required. LumaCyte’s Radiance instrument uses a unique combination of advanced optics and microfluidics to automatically identify and characterize cells of interest based upon key intrinsic biophysical and biochemical cellular properties and dynamics. Laser Force Cytology (LFC) delivers a more robust and powerful sample analysis compared with conventional label-based flow cytometry.
Label-Free LFC™ Analysis
The biopharmaceutical world is evolving rapidly, bringing with it the need for innovative technologies to support this fast-paced and changing environment. LumaCyte’s advanced bioanalytics platform, Radiance®, is a label-free, single cell approach for quantitative characterization of innate cellular responses without the need for antibody or genetic labeling. This revolutionary technology utilizes Laser Force Cytology™ (LFC™) to measure cellular response and changes to their intrinsic biochemical and biophyscial properties by measuring optical and fluidic forces on cells in a microfluidic device. Subtle cellular changes can be precisely captured with Radiance’s automated workflow, allowing developers to measure real-time product quality attributes and immediately optimize processes, significantly improving both production quality and product yields. This includes both in-process analytics to inform and optimize the production process as well as offline release and potency assays used to ensure product quality and consistency.
LFC detects subtle phenotypic changes in cells, rapidly measuring quantitative early indicators of cellular response including viral infection, transfection and differentiation.
The Value of Label-Free LFC™ Analysis
Opening the Door to New Cellular Insights
- Protects the innate cellular response through a label-free measurement approach
- Reduces errors in assay results through unbiased cellular measurements
- Enables discoveries of new cells, phenotypes, and cellular biomarkers
- Delivers higher quality results with less time and cost
Advanced bioanalytics are becoming a vital component of a successful Quality by Design (QbD) biomanufacturing program, where accurate and precise real-time data hold the keys to improved production consistency and product quality. LumaCyte’s label-free single-cell analysis platform, Radiance®, using Laser Force Cytology™ (LFC™), delivers advanced analytics for real-time bioprocess monitoring and quality control strategies.
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LumaCyte Force Cytology
1:31 duration
Our Technology
LumaCyte Laser Force Cytology™ (LFC) is transforming the status quo through its novel label-free, single cell advanced analytics. This revolutionary technology measures optical and fluidic forces on cells based upon intrinsic cellular dynamics and without the need for antibody or genetic labeling. LFC brings new bioprocess knowledge that enables rapid optimization and provides scientists a real-time view into the subtle phenotypic changes occurring across their development and production assays.
Platform Instruments
Radiance®, is a label-free, single cell solution for quantitative characterization of innate cellular responses where the use of antibody or fluorescent labeling is not required. Radiance® LFC optical and hydrodynamic force measurements are delivering real-time bioprocess and production data insights that enable rapid optimization of key quality control strategies, where accurate and precise real-time data hold the keys to both, accelerated development and improved production consistency.
Solutions
ReportR™, LumaCyte’s fully automated cloud-based analysis and report generation software platform, takes the Radiance® user experience to the next level, delivering a more robust and efficient approach to traditional data analysis efforts. Experimental details are entered only once and then seamlessly carried through data acquisition, analysis, and reporting, maximizing efficiency, and ensuring experimental consistency. LumaCyte’s end-to-end ReportR™ offering streamlines laboratory workflows and accelerates time to results (TTR).
Our Technology
Advanced bioanalytics are becoming a vital component of a successful Quality by Design (QbD) biomanufacturing program, where accurate and precise real-time data hold the keys to improved production consistency and product quality. LumaCyte’s label-free single-cell analysis platform, Radiance®, using Laser Force Cytology™ (LFC™), delivers advanced analytics for real-time bioprocess monitoring and quality control strategies.
